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creatine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4661 | 57-00-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 48 | |||
| kinase-selectivity-class | ACVR2B,AXL,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,STK33,TEK,TGFBR1 | 11 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia aspiration | 255.89 | 69.96 | 57 | 495 | 40883 | 90587012 |
| Coma | 223.39 | 69.96 | 57 | 495 | 72575 | 90555320 |
| Gastrooesophageal reflux disease | 180.82 | 69.96 | 58 | 494 | 166279 | 90461616 |
| Somnolence | 163.87 | 69.96 | 57 | 495 | 209027 | 90418868 |
| Underdose | 97.46 | 69.96 | 28 | 524 | 53989 | 90573906 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Focal segmental glomerulosclerosis | 39.99 | 35.37 | 8 | 329 | 2540 | 42618458 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia aspiration | 203.65 | 37.60 | 58 | 848 | 81175 | 110507218 |
| Coma | 178.18 | 37.60 | 57 | 849 | 117812 | 110470581 |
| Gastrooesophageal reflux disease | 158.26 | 37.60 | 58 | 848 | 179918 | 110408475 |
| Somnolence | 133.27 | 37.60 | 59 | 847 | 297390 | 110291003 |
| Underdose | 88.55 | 37.60 | 29 | 877 | 63525 | 110524868 |
| Incorrect route of product administration | 46.33 | 37.60 | 18 | 888 | 64043 | 110524350 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:50733 | nutraceutical |
| CHEBI has role | CHEBI:63726 | neuroprotective agent |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
| CHEBI has role | CHEBI:176497 | geroprotector |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.48 | acidic |
| pKa2 | 11.13 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4024927 | VUID |
| N0000170276 | NUI |
| 4024927 | VANDF |
| CHEBI:16919 | CHEBI |
| CRN | PDB_CHEM_ID |
| CHEMBL283800 | ChEMBL_ID |
| 4496 | IUPHAR_LIGAND_ID |
| DB00148 | DRUGBANK_ID |
| MU72812GK0 | UNII |
| 2907 | RXNORM |
| NOCODE | MMSL |
| d04417 | MMSL |
| 008272 | NDDF |
| C0010286 | UMLSCUI |
| D003401 | MESH_DESCRIPTOR_UI |
| 586 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ginsamin Energy | HUMAN OTC DRUG LABEL | 5 | 44738-7001 | LIQUID | 10000 mg | ORAL | unapproved drug other | 3 sections |